Colossal Biosciences has introduced GenoMorph, an artificial intelligence platform designed to identify genetic changes that could help recreate characteristics of extinct species. Announced on October 14, 2026, the technology has identified approximately 2,300 potential gene-editing targets associated with the dodo bird’s skull and facial structure, which researchers will now test in laboratories.
According to Colossal’s official announcement, GenoMorph combines 3D anatomical measurements, comparative genomics, and developmental biology to analyze species with limited genetic information. The company developed the platform over more than a year to support its ongoing de-extinction research.
How GenoMorph Identifies Genetic Traits of Extinct Species
Colossal’s dodo research currently relies on one available genome, compared with approximately 100 woolly mammoth genomes used in another of its de-extinction projects. The difference reflects how ancient DNA is preserved, with colder environments generally protecting genetic material better than tropical climates.
To address the limited data, Colossal trained GenoMorph using developmental information from chickens, quail, ducks, and pigeons. Researchers combined these findings with genetic information and 3D skull measurements from more than 70 bird species to identify DNA regions associated with physical characteristics.
The AI analyzes which genetic regions are active during the development of birds’ beaks and facial structures. It then predicts which regulatory DNA elements may have contributed to the dodo’s distinctive appearance.
According to CEO and co-founder Ben Lamm, the platform has identified approximately 2,300 candidate DNA targets related to the dodo’s craniofacial structure. However, these predictions still require experimental validation before researchers can determine whether the proposed changes produce the intended physical characteristics.
Colossal Develops New Methods for Testing Gene Edits
Colossal has also developed a method that uses lipid nanoparticles to deliver gene-editing tools into developing bird embryos. The approach allows researchers to investigate how genetic modifications affect physical development without waiting for birds to mature and reproduce.
The company reported that its Nicobar pigeon breeding colony has expanded to 36 birds. Researchers have also successfully developed primordial germ cells, which eventually produce eggs and sperm, as part of their efforts to introduce dodo-like traits into the species.
The Nicobar pigeon is the dodo’s closest living relative, making it an important part of Colossal’s research. Lamm emphasized that GenoMorph identifies potential genetic changes but does not perform the edits itself, and predicted targets must undergo safety assessments and laboratory testing.
New Investment Firm to Support Colossal’s Biotechnology Platform
Alongside the announcement, XPRIZE founder and Colossal investor Peter Diamandis introduced NeoGenesis Capital, a venture capital firm focused on companies using Colossal’s programmable biology technology.
The investment firm plans to support businesses applying genetic engineering and related biotechnology across healthcare, agriculture, and conservation. Diamandis announced the venture on October 14, expanding investment opportunities associated with Colossal’s research and technology platform.
Featured image credits: Wikimedia Commons
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